| Product Name | SP17 Antibody (H-111) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 41-151 mapping at the C-terminus of SP17 of human origin |
| Modification Notes | SP17 (sperm protein 17), also known as SPA17 (sperm autoantigenic protein 17), SP17-1 or CT22 (cancer/testis antigen 22), is a sperm surface peripheral membrane protein. It is predominantly expressed in testis and contains two heparan binding motifs and a C-terminal calmodulin (CaM)-binding domain. SP17 exists as a homodimer and localizes to the head and tail of spermatozoa. Residing in the fibrous sheath of the tail, SP17 interacts, via its N-terminus, with AKAP 3 and may play an important signaling role in this PKA-independent AKAP complex. Localizing to the cytoplasm of the head of spermatozoa, SP17 can bind to the zona pellucida of the oocyte with high affinity, suggesting a role in fertilization. In addition, SP17 has been identified as a cancer/testis antigen and is expressed in ovarian cancer and multiple myeloma. This suggests that SP17 could be suitable as a target in tumor immunotherapy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SP17 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 41-151 mapping at the C-terminus of SP17 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 41-151 mapping at the C-terminus of SP17 of human origin |
| Entrez Gene | 53340 |
|---|
| Application Notes | recommended for detection of SP17 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
