| Product Name | FGD6 Antibody (H-175) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 998-1172 mapping within an internal region of FGD6 of human origin |
| Modification Notes | Members of the FGD family, including FGD1, FGD2, FGD3, FGD4, FGD5 and FGD6, encode guanine nucleotide exchange factors that specifically activate the Rho GTPase Cdc42. All FGD proteins contain equivalent signaling domains and a conserved structural organization, which strongly suggests that these signaling domains form a canonical core structure for members of the FGD family of RhoGEF proteins. These proteins also control essential signals required during embryonic development. FGD6 (FYVE, RhoGEF and PH domain containing 6), also known as ZFYVE24 (zinc finger FYVE domain-containing protein 24), is a 1,430 amino acid cytoplasmic protein that belongs to the FGD family and exists as two alternatively spliced isoforms. Thought to activate Cdc42 by exchanging bound GDP for free GTP, FGD6 is also implicated in maintenance of the actin cytoskeleton and regulating cell shape. Encoded by a gene that maps to human chromosome 12q22, FGD6 contains one FYVE-type zinc finger, two PH domains and a single DH (DBL-homology) domain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FGD6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 998-1172 mapping within an internal region of FGD6 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 998-1172 mapping within an internal region of FGD6 of human origin |
| Application Notes | recommended for detection of FGD6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
