| Product Name | R7BP Antibody (FL-246) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against amino acids 12-257 mapping at the C-terminus of R7BP of human origin |
| Modification Notes | The regulators of G protein signaling (RGS proteins) bind directly to the G protein å (Gå) subunits in brain and other tissues to determine the strength, duration and fidelity of neurotransmitter receptor signaling. They also regulate the kinetics of the G protein signaling. Members of the R7 subfamily, part of the RGS family, bind to G∫ 5 (R7-G∫ 5) and shuttle between the plasma membrane and the nucleus with assistance from a shuttle protein, R7BP, in neurons. R7BP binds directly to R7-G∫ 5, and the protein complex becomes tethered to the plasma membrane by the addition of palmitate, a lipid, onto R7BP. Removal of palmitate results in the translocation of the R7BP-R7-G∫ 5 complex to the nucleus, presumably for nontraditional signaling functions. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of R7BP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against amino acids 12-257 mapping at the C-terminus of R7BP of human origin |
|---|---|
| Tissue Specificity | raised against amino acids 12-257 mapping at the C-terminus of R7BP of human origin |
| Application Notes | recommended for detection of R7BP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
