| Product Name | nephrocystin-4 Antibody (H-67) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1116-1182 mapping within an internal region of nephrocystin-4 of human origin |
| Modification Notes | The nephrocystin proteins comprise a family of five enzymes that commonly interact with p130Cas, proline-rich tyrosine kinases, calmodulin, and tensin, indicating that these proteins may participate in a common signaling pathway. Nephrocystin-4 is a 1,250-amino acid protein that interacts with signaling molecules involved in cell adhesion and organization of the actin cytoskeleton, such as Pyk2, tensin, and filamins. Nephrocystin-4 colocalizes with PKD-2 in the transition zones of ciliated sensory endings of dendrites, and, together, they play an important role in facilitating ciliary sensory signal transduction. Mutations in the Nephrocystin-4 gene contribute to the disease nephronophthisis, an autosomal-recessive cystic kidney disease. Clinical features of familial juvenile nephronophthisis include anemia, polyuria, polydipsia, isosthenuria, and death. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of nephrocystin-4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1116-1182 mapping within an internal region of nephrocystin-4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1116-1182 mapping within an internal region of nephrocystin-4 of human origin |
| Entrez Gene | 261734 |
|---|
| Application Notes | recommended for detection of nephrocystin-4 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
