Application
Western blot analysis of Factor XI expression in non-transfected (A) and human Factor XI transfected (B) F11 293T whole cell lysates.| Product Name | Factor XI Antibody (H-76) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 111-186 mapping near the N-terminus of Factor XI of human origin |
| Modification Notes | Coagulation Factor XI (FXI) is a glycoprotein produced by platelets and megakaryocytes in the liver and circulates as a zymogen homodimer in plasma. Factor XI is a trypsin-like plasma serine protease that catalyzes the activation of the consolidation phase of blood coagulation through a Thrombin-generated feedback loop. The plasma half-life of Factor XI is about 52 hours, and plasma concentrations are usually 5 mg/l. During hemostasis, the coagulation protease factor (Factor XIa) activates Factor XI. Factor XI deficiency (Hemophilia C) is an injury-related bleeding disorder that leads to a variable bleeding tendency which is inherited in an autosomal recessive manner, though is not completely recessive, because heterozygotes also have a mild but definite bleeding tendency. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Factor XI of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 111-186 mapping near the N-terminus of Factor XI of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 111-186 mapping near the N-terminus of Factor XI of human origin |
Application
Western blot analysis of Factor XI expression in non-transfected (A) and human Factor XI transfected (B) F11 293T whole cell lysates.| Application Notes | recommended for detection of Factor XI of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
