| Product Name | Ninein Antibody (H-188) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 289-476 mapping near the N-terminus of Ninein of human origin |
| Modification Notes | Ninein is a centrosomal protein necessary for the positioning and anchorage of the microtubule minus-end in epithelial cells. The protein is presumably a centrosome maturation factor and may play a role in microtubule nucleation. Overexpression of Ninein does not alter nucleation or elongation of microtubules, but rather suppresses their release. Ninein associates with GSK3B (GSK3-b) via its C-terminal domain, and also interacts with C14orf166; the latter is thought to prevent phosphorylation of Ninein by GSK-3b. Ninein is a component of the core centrosome, where it is arranged in a tubular conformation with its open and closed ends contained within the centrosome. It demonstrates ubiquitous expression and shows predominant expression in heart and skeletal muscle tissues. The coiled-coil region from Asn 1611 to Pro 1693 is necessary for targeting Ninein to the centrosome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Ninein of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 289-476 mapping near the N-terminus of Ninein of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 289-476 mapping near the N-terminus of Ninein of human origin |
| Entrez Gene | 51199 |
|---|
| Application Notes | recommended for detection of Ninein of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
