| Modification Notes |
Formin-like protein 2 (FMNL2, Formin homology 2 domain-containing protein 2, FHOD2) is a 1,087 amino acid protein encoded by the human gene FMNL2. FMNL2 belongs to the formin homology family and has one DAD (diaphanous autoregulatory) domain, one FH2 (formin homology 2) domain, and one GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. Formins are a conserved class of proteins expressed in all eukaryotes, with known roles in generating cellular actin-based structures. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. FMNL2 is believed to play a role in the control of cell motility and survival of macrophages. |