| Modification Notes |
Chronic lymphocytic leukemia (CLL) is an incurable disease characterized by the presence of small mature lymphocytes, intense accumulation of monoclonal B cells and a characteristic CD5 and CD19 co-expression phenotype. While the clinical course of CLL can be highly variable, a CLL specific protein known as CLLU1 (chronic lymphocytic leukemia up-regulated 1) is expressed in CLL patients, with high CLLU1 expression associated with shorter overall survival. Consisting of 121 amino acids, CLLU1 has been predicted to interact with interleukin 4 receptor (IL-4R) and is encoded by a gene located on human chromosome 12. CLLU1OS (chronic lymphocytic leukemia up-regulated 1 opposite strand) is a 101 amino acid protein encoded by a gene that maps to human chromosome 12q22. |