| Product Name | CSMD1/2/3 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 21-320 mapping near the N-terminus of CSMD3 of human origin |
| Modification Notes | The CUB and sushi domain-containing proteins, CSMD1-3, are membrane proteins that are involved in cell-cell adhesion and are weakly expressed in most tissues, with higher levels of expression observed in the cerebellum and hippocampus. CSMD1 is part of the complement system that defends against pathogens through either the classical pathway or the alternative pathway. Located primarily in nerve growth cones, CSMD1 blocks the classical pathway of the immune system and is thought to be involved in tumor suppression, as defects in the gene encoding CSMD1 are associated with squamous cell carcinomas. CSMD2 and CSMD3 are located primarily in the brain and are implicated in some forms of head and neck cancer. Additionally, the CSMD3 gene is a candidate for induction of epileptic seizures. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CSMD1, CSMD2 and CSMD3 of human origin, and CSMD1 and CSMD3 of mouse and rat origin by WB, IP, IF and ELISA non cross-reactive with CSMD2 of mouse and rat origin also reactive with additional species, including equine, canine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 21-320 mapping near the N-terminus of CSMD3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 21-320 mapping near the N-terminus of CSMD3 of human origin |
| Entrez Gene | 64478 |
|---|
| Application Notes | recommended for detection of CSMD1, CSMD2 and CSMD3 of human origin, and CSMD1 and CSMD3 of mouse and rat origin by WB, IP, IF and ELISA non cross-reactive with CSMD2 of mouse and rat origin also reactive with additional species, including equine, canine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
