| Modification Notes |
The peptidase M14 family of carboxypeptidases (CPs) are involved in various functions throughout the body which include digestion of food and biosynthesis of peptides that function in intercellular signaling. CCP6 (Cytosolic carboxypeptidase 6), also known as AGBL4 (ATP/GTP binding protein-like 4), is a 540 amino acid cytoplasmic protein that is expressed in testis, pituitary and brain, with more moderate expression observed in eye, stomach, kidney and adrenal tissue. It is suggested that CCP6 may be involved in processing of cytosolic proteins such as å Tubulin. The gene encoding CCP6 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1 which include Hutchinson-Gilford progeria, familial adenomatous polyposis, Parkinsons, Gaucher disease and Usher syndrome. |