Application
Western blot analysis of Laforin expression in HeLa whole cell lysate.| Product Name | Laforin Antibody (H-220) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 81-260 mapping within an internal region of Laforin of human origin |
| Modification Notes | Laforin (Lafora PTPase) is a dual specificity protein phosphatase expressed in heart, skeletal muscle, kidney, pancreas and brain. It belongs to the protein-tyrosine phosphatase family and contains one CBM20 (carbohydrate binding type-20) domain and one tyrosine-protein phosphatase domain. Laforin may be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans). Laforin isoform 1 is primarily associated with polyribosomes at the endoplasmic reticulum, however, it is also found at the plasma membrane. Isoform 2 can be found in the nucleus. Defects in the EPM2A gene are a cause of progressive myoclonic epilepsy type 2 (EPM2), also known as Lafora disease. EPM2 is an autosomal recessive disease and a severe form of adolescent-onset progressive epilepsy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Laforin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 81-260 mapping within an internal region of Laforin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 81-260 mapping within an internal region of Laforin of human origin |
| Entrez Gene | 7957 |
|---|
Application
Western blot analysis of Laforin expression in HeLa whole cell lysate.| Application Notes | recommended for detection of Laforin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
