| Product Name | PCOTH Antibody (G-18) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of PCOTH of human origin |
| Modification Notes | PCOTH (Prostate collagen triple helix protein) is a 107 amino acid cytoplasmic protein that is specifically expressed in prostate and testis. PCOTH may play a significant role in the proliferation and viability of prostate cancers by way of phosphorylating the oncoprotein I2PP2A. Knockdown of PCOTH mRNA results in the drastic reduction of prostate cancer cell growth and viability, whereas addition of PCOTH results in enhanced cancer cell growth. Interestingly, prostate cancer cells that overexpressed PCOTH had significantly increased levels of phosphorylated I2PP2A and Calregulin. I2PP2A has a variety of functions such as involvement in regulating cell cycle transition and acting as an inhibitor of PP2A. Calregulin plays an important role in the modulation of gene transcription. Therefore, the inhibition of PCOTH modulation may be a potential treatment approach for prostate cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of PCOTH of human origin by WB, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of PCOTH of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of PCOTH of human origin |
| Entrez Gene | 542767 |
|---|
| Application Notes | recommended for detection of PCOTH of human origin by WB, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
