Application
Western blot analysis of SLC46A3 expression in non-transfected: (A) and mouse SLC46A3 transfected: (B) 293T whole cell lysates.| Product Name | SLC46A3 Antibody (N-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of SLC46A3 of human origin |
| Modification Notes | The major facilitator superfamily consists of presumed carbohydrate transporters with 10-12 membrane-spanning domains. SLC46A3 (solute carrier family 46, member 3), also known as FKSG16, is a 461 amino acid multi-pass membrane protein belonging to the major facilitator superfamily. SLC46A3 exists as three alternatively spliced isoforms and is encoded by a gene located on human chromosome 13. Comprising nearly 4% of human DNA, chromosome 13 contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is also located on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SLC46A3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of SLC46A3 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of SLC46A3 of human origin |
| Entrez Gene | 283537 |
|---|
Application
Western blot analysis of SLC46A3 expression in non-transfected: (A) and mouse SLC46A3 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of SLC46A3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
