| Product Name | Abin-2 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 mapping at the N-terminus of Abin-2 of human origin |
| Modification Notes | The nuclear factor NF kappaB is essential for the regulation of immune response genes, inflammatory processes and apoptosis. Abin-2 (also designated A20-binding inhibitor of NF kappaB activation 2) is an intracellular zinc-finger protein that inhibits the expression of NF kappaB by recruiting a chromatin-remodeling complex to the target gene. Abin-2, a p105-associated protein, is a potent inhibitor of TNF-induced cell death. Abin-2 can also associate with TPL-2, and in endogenous tissues it is frequently associated with both TPL-2 and p105. siRNA depletion of Abin-2 has been found to reduce levels of TPL-2 but not of p105, which indicates that Abin-2 is involved in the TLR4 signaling pathway. Abin-2 inhibits endothelial apoptosis, but upon deletion of the carboxy-terminus of the protein, its ability to inhibit apoptosis is removed. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of Abin-2 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of Abin-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of Abin-2 of human origin |
| Entrez Gene | 79155 |
|---|
| Application Notes | recommended for detection of Abin-2 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
