| Product Name | PREP Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 mapping at the N-terminus of PREP (Prolyl endopeptidase) of human origin |
| Modification Notes | PREP (prolyl endopeptidase), also known as PE or PEP, is a 710 amino acid protein that localizes to the cytoplasm and belongs to the peptidase S9A family. Existing as a monomer, PREP functions as a prolyl endopeptidase that specifically cleaves peptide bonds on the C-terminal side of prolyl residues within proteins that are approximately 30 amino acids long. Via its catalytic activity, PREP is thought to be involved in the formation and degradation of neuropeptides and hormones, indicating involvement in signaling and regulatory pathways throughout the body. The gene encoding PREP maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PREP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of PREP (Prolyl endopeptidase) of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of PREP (Prolyl endopeptidase) of human origin |
| Entrez Gene | 5550 |
|---|
| Application Notes | recommended for detection of PREP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
