| Modification Notes |
NUDT18 (nudix (nucleoside diphosphate linked moiety X)-type motif 18) is a 323 amino acid protein that contains one nudix hydrolase domain and belongs to the nudix hydrolase family. Using magnesium or manganese as cofactors, NUDT18 is thought to mediate the hydrolysis of select nucleoside diphosphate derivatives. Multiple isoforms of NUDT18 exist due to alternative splicing events. The gene encoding NUDT18 maps to human chromosome 8, which encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that maps to chromosome 8. |