Application
Western blot analysis of non-phosphorylated (A) and phosphorylated (B) rat recombinant TH fusion proteins.| Product Name | p-TH Antibody (Ser 40) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of Ser 40 phosphorylated TH of rat origin by WB, IP and IF |
| Modification | Phosphoralated |
| Modification Notes | The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-DOPA. This is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin.Protein Kinase A (PKA) mediated phosphosphorylation at Serine 40 causes increased TH catalytic activity. Expressed mainly in the brain and adrenal glands, TH may play a role in the pathogenesis of Parkinson’s disease and the associated reduction in dopamine levels. The human tyrosine hydroxylase gene maps to 11p15. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIF |
| See 1 citations for p-THAntibody (Ser 40): |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Ser 40 phosphorylated TH of rat origin by WB IP and IF |
|---|---|
| Tissue Specificity | recommended for detection of Ser 40 phosphorylated TH of rat origin by WB, IP and IF |
Application
Western blot analysis of non-phosphorylated (A) and phosphorylated (B) rat recombinant TH fusion proteins.| Application Notes | See 1 citations for p-THAntibody (Ser 40): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
