| Product Name | Bcl-9 Antibody (H-250) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 521-770 mapping within an internal region of BCL-9 of human origin |
| Modification Notes | Bcl-9 (B-cell CLL/lymphoma 9 protein) is a nuclear protein encoded by the human gene BCL9. Bcl-9 belongs to the BCL9 family and is involved in the Wnt signaling pathway. The Wnt signaling pathway controls numerous cell fates during animal development. A malfunction in Wnt signaling activity can lead to cancer in many human tissues. A key effector of the canonical Wnt pathway is b-catenin (or Drosophila Armadillo), a highly unstable phosphorylated protein that shuttles rapidly between nucleus and cytoplasm. A nuclear complex, consisting of Bcl-9/Bcl-9L, b-catenin and other proteins, activates transcription of several Wnt target genes, including FGF-20, WISP-1, Myc, and Glucagon. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BCL-9 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 521-770 mapping within an internal region of BCL-9 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 521-770 mapping within an internal region of BCL-9 of human origin |
| Entrez Gene | 607 |
|---|
| Application Notes | recommended for detection of BCL-9 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
