Ribosomes, the organelles that catalyze protein synthesis, are composed of a small subunit (40S) and a large subunit (60S) that consist of over 80 distinct ribosomal proteins. Ribosomal Protein LP0, also known as RPLP0, P0, L10E or RPP0, is a 317 amino acid cytoplasmic protein that is the human ortholog of the yeast L10 ribosomal protein. One of several components of the 60S ribosomal subunit, Ribosomal Protein LP0 functions as a neutral phosphoprotein that shares high similarity with Ribosomal Protein LP1 and Ribosomal Protein LP2. Together, these proteins form a pentameric complex (comprised of LP1 and LP2 dimers and one LP0 monomer) that regulates ribosome assembly and plays a role in translation initiation. Overexpression of Ribosomal Protein LP0 is associated with liver and breast cancer, suggesting a role for Ribosomal Protein LP0 in tumorigenesis. Like other mammalian ribosomal proteins, Ribosomal Protein LP0 exists as multiple processed pseudogenes that are found throughout the genome.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of Ribosomal Protein LP0 of human and canine origin by WB, IP and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
raised against Ribosomal Protein LP0 of human origin
Tissue Specificity
raised against Ribosomal Protein LP0 of human origin