| Product Name | PYPAF7 Antibody (H-77) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Pyrin-containing Apaf1-like proteins (PYPAFs) are members of the nucleotide-binding site/leucine-rich repeat (NBS/LRR) family of signal transduction proteins that function in apoptotic and inflammatory signaling pathways. PYPAF7, also known as Monarch-1, regulates activation of caspase-1 via ASC protein and promotes activation of NF-kappa-B via IKK. PYPAF7 enhances nonclassical and classical MHC class I expression at the level of the promoter, RNA, and protein expression. PYPAF7 is present in the cytoplasm of peripheral blood leukocytes, predominantly eosinophils and granulocytes, with lower levels in monocytes. The PYPAF7 gene maps to human chromosome 19q13.4. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PYPAF7 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 985-1061 mapping at the C-terminus of PYPAF7 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 985-1061 mapping at the C-terminus of PYPAF7 of human origin |
| Application Notes | recommended for detection of PYPAF7 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
