| Product Name | NALP7 Antibody (H-155) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Most short NALPs, such as NALP7 (PYPAF3), have a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin (MEFV) domain (PYD) followed by a NACHT domain, and a NACHT-associated domain (NAD). NALP7, which de-monstrates expression in several tissues, including uterus and ovary, while showing low levels of expression in heart and brain tissues, inhibits CASP1/caspase-1-dependent IL-1b secretion through a direct interaction with CASP1 and IL-1b. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM), an abnormal human pregnancy with no embryo and cystic degeneration of placental villi. Knockdown of the NALP7 gene via RNA interference reduces the growth of carcinoma cell lines, leading to the conclusion that NALP7 may play a crucial role in cell proliferation. The NALP7 gene maps to chromosome 19q13.42, within a cluster of many other NALP genes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NALP7 isoforms 1 and 2 of human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 16-170 mapping near the N-terminus of NALP7 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 16-170 mapping near the N-terminus of NALP7 of human origin |
| Entrez Gene | 199713 |
|---|
| Application Notes | recommended for detection of NALP7 isoforms 1 and 2 of human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
