Application
Western blot analysis of FBXO6/44 expression in Caki-1 whole cell lysate.| Product Name | FBXO6/44 Antibody (H-51) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 6-56 mapping near the N-terminus of FBXO6 of human origin |
| Modification Notes | F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for proteasomal degradation. FBXO44 (F-box only protein 44), also known as FBG3, FBX30, FBX44, FBX6A or FBXO6A, is a 255 amino acid protein that contains one F-box domain and one FBA domain and functions as a component of the SCF complex. Expressed abundantly in kidney and brain and present at lower levels in liver, heart and spleen, FBXO44 exists as multiple alternatively spliced isoforms and is thought to be involved in E3 ubiquitin ligase-related events throughout the cell. FBXO6 is another member of the F-box family and is thought to be involved in cell cycle control in tissues such as liver, testis and brain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FBXO6 and FBXO44 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 6-56 mapping near the N-terminus of FBXO6 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 6-56 mapping near the N-terminus of FBXO6 of human origin |
| Entrez Gene | 26270 |
|---|
Application
Western blot analysis of FBXO6/44 expression in Caki-1 whole cell lysate.| Application Notes | recommended for detection of FBXO6 and FBXO44 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
