| Product Name | PCP-2 Antibody (H-60) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-60 mapping at the N-terminus of PCP-2 of human origin |
| Modification Notes | Purkinje cells are densely branching neurons characteristic of the cerebellar cortex. Purkinje cell protein-2 (PCP-2 or L7) is a G protein regulator abundant in Purkinje cells and retinal bipolar neurons. PCP-2 belongs to a family of proteins containing a GoLoco or GPR (G protein regulatory) motif named for the Gi/o interacting protein Loco, the Drosophila RGS12 homologue. PCP-2 protein interacts with Gåi/o family of G proteins to inhibit GDP release. This indicates that the colocalization and association of Gåi/o and PCP-2 in cerebellum may play a functional role in regions of synaptic activity, as well as neural differentiation. The Purkinje type calcium channels may be physiological effectors of PCP-2 because they are the major voltage-dependent channels that modulate cell output and they are regulated by Gi/o proteins. PCP-2 is only detected in higher vertebrates, suggesting that it may be a marker of more recent evolutionary development of cerebellar Purkinje cells. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PCP-2 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-60 mapping at the N-terminus of PCP-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-60 mapping at the N-terminus of PCP-2 of human origin |
| Entrez Gene | 126006 |
|---|
| Application Notes | recommended for detection of PCP-2 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
