| Modification Notes |
The Kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual Kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events, including endocytosis and transcytosis. KIF16B (kinesin family member 16B), also known as SNX23 (Sorting nexin-23) or C20orf23, is a 1,317 amino acid protein that contains one FHA domain, one kinesin-motor domain and one PX domain and belongs to the Kinesin-like protein family. Present in early endosomes at the end of microtubules, KIF16B is thought to function as a microtubule-dependent motor protein that may regulate the motility of early endosomes, thereby mediating the balance between endosomal recycling and degradation. Five isoforms of KIF16B are expressed due to alternative splicing events. |