Application
Western blot analysis of SMOC-2 expression in A-10 (A) and C2C12 (B) whole cell lysates and rat skeletal muscle (C) and mouse heart (D) tissue extracts.| Product Name | SMOC-2 Antibody (H-53) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | SMOC-2 (SPARC-related modular calcium-binding protein-2), also known as SMAP2, MST117, MSTP117 or MSTP140, is a secreted modular calcium-binding glycoprotein found in the extracellular space. SMOC-2 is a member of the SPARC/BM-40 family and contains two EF-hand domains, one Kazal-like domain and two thyroglobulin type-1 domains. The SPARC/BM-40 family has been implicated in tissue remodeling, angiogenesis and bone mineralization. SMOC-2 is a widely expressed protein with highest expression levels found in spleen, ovary, muscle and heart tissues. SMOC-2 may interact directly with VEGF or FGF and is believed to participate in angiogenic activity, cell proliferation and migration. In addition, SMOC-2 is required for efficient growth factor-induced DNA synthesis, and its overexpression greatly stimulates DNA synthesis. For this reason, SMOC-2 is a potential target for anti-angiogenic therapies. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SMOC-2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 71-123 mapping near the N-terminus of SMOC-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 71-123 mapping near the N-terminus of SMOC-2 of human origin |
| Entrez Gene | 64094 |
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Application
Western blot analysis of SMOC-2 expression in A-10 (A) and C2C12 (B) whole cell lysates and rat skeletal muscle (C) and mouse heart (D) tissue extracts.| Application Notes | recommended for detection of SMOC-2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
