Application
Western blot analysis of PDGF-C expression in MDA-MB-231 whole cell lysate (A) and mouse colon (B) and mouse prostate (C) tissue extracts.| Product Name | PDGF-C Antibody (H-125) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 126-250 mapping within an internal region of PDGF-C of human origin |
| Modification Notes | Platelet-derived growth factor (PDGF) refers to a family of disulphide-bonded dimeric isoforms that are important for growth and survival, and which function in several types of connective tissue cells. PDGF, which is a major mitogen for vascular smooth muscle cells and is implicated in the pathogenesis of arteriosclerosis, is composed of dimers of PDGF-A and PDGF-B polypeptide chains encoded by different genes. PDGF-C (also designated spinal cord-derived growth factor, SCDGF or fallotein) is a functional analog of PDGF-A that requires proteolytic activation. PDGF-A and PDGF-C selectively activate PDGFR-a, whereas PDGF-B activates both PDGFR-a and PDGFR-b. PDGF-C expression in the arterial wall and cultured vascular cells suggests that it can transduce proliferation/migration signals to pericytes and smooth muscle cells. Additionally, PDGF-C is a target of EWS/ETS transcriptional deregulation and this transcriptional deregulation is specific to EWS/FLI. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PDGF-C of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 126-250 mapping within an internal region of PDGF-C of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 126-250 mapping within an internal region of PDGF-C of human origin |
| Entrez Gene | 56034 |
|---|
Application
Western blot analysis of PDGF-C expression in MDA-MB-231 whole cell lysate (A) and mouse colon (B) and mouse prostate (C) tissue extracts.| Application Notes | recommended for detection of PDGF-C of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
