Application
Western blot analysis of VRL-1 expression in mouse cerebellum tissue extract.| Product Name | VRL-1 Antibody (H-105) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-105 mapping at the N-terminus of VRL-1 of human origin |
| Modification Notes | Transient receptor potential (Trp) ion channels are a superfamily of six transmembrane segment-spanning, gated cation channels. Trp subtypes mediate store-operated Ca2+ entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. Trp ion channels influence calcium-depletion induced calcium influx processes in response to chemo-, mechano- and osmoregulatory events. A subset of Trp channels includes the vanilloid receptor 1 (VR1), VRL-1, and TRPM8, which are involved in temperature perception. VR1 is activated by temperatures exceeding 43 degrees Celsius and by capsaicin, the main ingredient in hot chili peppers. VRL-1 is activated by extreme temperatures exceeding 52 degrees Celsius, and is expressed in both neuronal and nonneuronal cells. TRPM8 is stimulated by cold temperatures below 22 degrees Celsius as well as methanol. TRPM8 is expressed in a subpopulation of pain and temperature-sensing dorsal root ganglia (DRG) neurons. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of VRL-1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-105 mapping at the N-terminus of VRL-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-105 mapping at the N-terminus of VRL-1 of human origin |
| Entrez Gene | 51393 |
|---|
Application
Western blot analysis of VRL-1 expression in mouse cerebellum tissue extract.| Application Notes | recommended for detection of VRL-1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
