Application
Western blot analysis of SMCHD1 expression in mouse brain tissue extract.| Product Name | SMCHD1 Antibody (A-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of SMCHD1 of human origin |
| Modification Notes | SMCHD1 (structural maintenance of chromosomes flexible hinge domain containing 1) is a 2,005 amino acid protein and novel modifier of epigenetic gene silencing. SMCHD1 may have a role in the hypermethylation of CpG islands associated with the maintenance of X chromosome inactivation. SMCHD1 exists as three alternatively spliced isoforms and is encoded by a gene located on human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases, representing about 2.5% of total DNA in cells. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas. Also, three chromosomal abnormalities result from meiotic nondisjunction events of chromosome 18: Monosomy 18p, Trisomy 18 (also known as Edwards syndrome) and Tetrasomy 18p. The LOC390856 gene product has been provisionally designated LOC390856 pending further characterization. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SMCHD1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of SMCHD1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of SMCHD1 of human origin |
| Entrez Gene | 23347 |
|---|
Application
Western blot analysis of SMCHD1 expression in mouse brain tissue extract.| Application Notes | recommended for detection of SMCHD1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
