| Modification Notes |
SPINK14 (serine peptidase inhibitor, Kazal type 14), also known as SPINK5L2 (serine protease inhibitor Kazal-type 5-like 2), is a 97 amino acid secreted protein that contains a Kazal-like serine protease inhibitor domain. Kazal-type serine proteinase inhibitors (SPINKs) are a family of protein molecules that contain at least one conserved Kazal domain with six cysteine residues forming three disulfide bonds in a 1-5, 2-4, and 3-6 pattern. The SPINK family has nine gene members in the human genome known as SPINK1, SPINK2, SPINK4, SPINK5, SPINK5L2 (SPINK14), SPINK5L3, SPINK6, SPINK7 and SPINK9. The gene that encodes SPINK14 maps to the 5q32 cytogenetic region of human chromosome 5, which is thought to be associated with hereditary disorders such as Netherton disease and immune system conditions such as type 1 diabetes and atopic dermatitis. |
