| Product Name | granulysin Antibody (H-130) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 16-145 representing full length mature granulysin of human origin |
| Modification Notes | Granulysin (NKG5) is a saposin-like protein (SAPLIP) that is expressed in granular cells and functions as an effector molecule for antimicrobial responses in the hematopoietic system. Upon antigen stimulation generated from intracellular pathogens such as bacteria, fungi, and parasites, granulysin mediates the release of cytotoxic granules from Cytolytic T lymphocytes (CTLs) and Natural killer cells (NKs), a process that can lead to apoptosis. The potent antimicrobial activity of granulysin may occur through elevated pathogen host-cell permeability and lysis. Human granulysin is expressed as proteins of two sizes derived from three unique transcripts. Granulysin expressing CTLs, in the presence of perforin, can kill extracellular and intracellular Mycobacterium tuberculosis through a granule-dependent mechanism, suggesting that granulysin may play a broad role in T cell mediated host protection against certain pathogens. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of precursor and mature forms of granulysin of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 16-145 representing full length mature granulysin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 16-145 representing full length mature granulysin of human origin |
| Entrez Gene | 10578 |
|---|
| Application Notes | recommended for detection of precursor and mature forms of granulysin of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
