| Product Name | Polycystin-1 Antibody (H-260) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of cysts in kidney tubules as well as in liver and pancreas tissues. Cells within these cysts display abnormalities in proliferation and polarity. The integral membrane protein, Polycystin-1 (PKD1) is mutated in a majority of patients with ADPKD. Polycystin-1 is expressed in renal tubular epithelial cells and colocalizes with cell and focal adhesion proteins, including E-cadherin, catenins, vinculin, and paxillin, to focal areas in order to form a larger multiprotein complex. Polycystin-1 is posttranslationally modified by tyrosine phosphorylation and associates with Polycystin-2 (PKD2) to mediate AP-1 expression, which suggests that Polycystin-1 is involved in cell-cell and cell-matrix interactions to control cell proliferation and polarity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Polycystin-1 of mouse, rat and human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 4044-4303 of Polycystin-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 4044-4303 of Polycystin-1 of human origin |
| Entrez Gene | 5310 |
|---|
| Application Notes | recommended for detection of Polycystin-1 of mouse, rat and human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
