| Product Name | PDE4B Antibody (H-56) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | PDE4B (phosphodiesterase 4B, cAMP-specific phosphodiesterase E4 dunce homolog, DPDE4, PDEIVB) catalyzes the hydrolysis of the second messenger cyclic adenosine 3',5' monophosphate (cAMP). PDE4B is a member of the type IV, cAMP-specific, cyclic nucleotide PDE family. Cyclic nucleotides are important second messengers that transmit cellular responses to extracellular signals, such as hormones, light and neurotransmitters. Altered activity of PDE4B may have an influence on schizophrenia and bipolar conditions. Tran-scription splice variants encoding different isoforms have been characterized. PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells, including monocytes and T lymphocytes. There are 11 families of PDEs that put together are responsible for the metabolism of cAMP and cGMP. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PDE4B isoforms 1-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 681-736 mapping at the C-terminus of PDE4B of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 681-736 mapping at the C-terminus of PDE4B of human origin |
| Entrez Gene | 5142 |
|---|
| Application Notes | recommended for detection of PDE4B isoforms 1-3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
