Application
Western blot analysis of X11γ expression in non-transfected: (A) and mouse X11γ transfected: (B) 293T whole cell lysates.| Product Name | X11γ Antibody (H-206) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-206 mapping at the N-terminus of x11γ of human origin |
| Modification Notes | The ∫-Amyloid precursor protein (∫-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The ∫-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular ∫-APP and slowing ∫-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of ∫-APP. Multiple splice varitents of X11 have been identified, including X11å (also designated Mint 1), X11∫ (Mint 2) and X11© (Mint 3). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of x11γ of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-206 mapping at the N-terminus of x11&gamma of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-206 mapping at the N-terminus of x11γ of human origin |
| Entrez Gene | 9546 |
|---|
Application
Western blot analysis of X11γ expression in non-transfected: (A) and mouse X11γ transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of x11γ of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
