| Product Name | ALY Antibody (H-154) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ALY (also designated THO complex subunit 4, THOC4, REF1, Refbp1 and BEF) is the mammalian homolog of the yeast mRNA export factor Yralp. A transcriptional coactivator, ALY belongs to the cytidylyltransferase family and is important in mRNA processing and export. During spliceosome assemby, it is recruited to messenger ribonucleoprotein (mRNP) complexes and becomes tightly associated with the spliced mRNP. Consistent with splicing-dependent recruitment, ALY co-localizes with splicing factors in the nucleus. It promotes transcriptional activation by promoting the dimerization of transcription factors containing basic leucine zipper domains. Although ubiquitously expressed, ALY specifically associates with the activation domains of LEF-1 and AML-1, both of which are protein components of the TCR a enhancer complex. Research indicates that ALY may mediate context-dependent transcriptional activation by facilitating the functional collaboration of multiple proteins in the TCR a enhancer complex. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ALY and RNA and export factor binding protein 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 102-255 mapping at the C-terminus of ALY of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 102-255 mapping at the C-terminus of ALY of human origin |
| Entrez Gene | 10189 |
|---|
| Application Notes | recommended for detection of ALY and RNA and export factor binding protein 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
