Application
Western blot analysis of JMJD8 expression in Jurkat whole cell lysate.Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining.Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human muscle tissue showing nuclear and cytoplasmic staining.| Product Name | JMJD8 Antibody (T-24) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | JMJD8 (Jumonji domain-containing protein 8) is a 334 amino acid protein that contains one Jumonji domain and is expressed as three isoforms produced by alternative splicing. The gene that encodes JMJD8 maps to human chromosome 16, which encodes over 900 genes in approximately 90 million base pairs, making up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16 through the CREBBP gene, which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of JMJD8 of human origin by WB, IP, IF, IHC(P) and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against JMJD8 of human origin |
|---|---|
| Tissue Specificity | raised against JMJD8 of human origin |
| Entrez Gene | 339123 |
|---|
Application
Western blot analysis of JMJD8 expression in Jurkat whole cell lysate.
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining.
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human muscle tissue showing nuclear and cytoplasmic staining.| Application Notes | recommended for detection of JMJD8 of human origin by WB, IP, IF, IHC(P) and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
