Application
Western blot analysis of TXA2R expression in platelet extract.| Product Name | TXA2R Antibody (H-120) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Thromboxane A2 (TXA2), the major cyclooxygenase (COX) product of arachidonic acid, stimulates platelet aggregation and is a potent vasoconstrictor (1). TXA2R has been implicated in several processes in normal kidney physiology as well as in myocardial infarction, atherosclerosis and bronchial asthma (1,2). TXA2 mediates its effects through the TXA2 receptor (TXA2R), a G protein-coupled receptor that activates phospholipase C (PLC) to mobilize intracellular calcium stores (1,3,4). Alternatively, TXA2R activates the MAP kinase pathway in response to dibutyryl cyclic AMP (dbcAMP) (3,4). The human TXA2R gene maps to chromosome 19p13.3 and is alternatively spliced to produce proteins which differ in the carboxy termini (2,4–6). TXA2R is expressed in platelets, endothelium, placenta, vascular smooth muscles and the renal cortex (6–9). Mutations in the gene encoding TXA2R lead to several bleeding disorders due to either impaired coupling between the receptor and PLC or impaired binding to TXA2 (6). Also, the TXA2R protein may be involved in mediating renal damage in disease states, controlling the initiation and/or progression of labor in women, and providing therapeutic value for treatment of acute pancreatitis (9–11). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TXA2R long and short isoforms of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-120 mapping at the N-terminus of TXA2R of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-120 mapping at the N-terminus of TXA2R of human origin |
| Entrez Gene | 6915 |
|---|
Application
Western blot analysis of TXA2R expression in platelet extract.| Application Notes | recommended for detection of TXA2R long and short isoforms of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
