| Product Name | SV2C Antibody (R-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | In all vertebrates, SV2 proteins are abundant, hydrophobic, membrane glycoproteins that are expressed as two major isoforms, SV2A and SV2B, and one minor isoform, SV2C. SV2 proteins are differentially expressed in the brain and are present on all synaptic vesicles, independent of transmitter type. While SV2A and SV2B are expressed ubiquitously througout the brain, SV2C displays a more restricted pattern of expression. SV2C is only present on a small subset of synapses in phylogenetically old brain areas, indicating that SV2C could be evolutionary more ancient than SV2A or SV2B. Specifically, SV2C is expressed in the central neuraxis, which includes the striatum, midbrain, hindbrain and the olfactory bulb. SV2C, whose molecular mass ranges due to N-glycosylation, contains cytoplasmic N-terminal and C-terminal domains. The restricted pattern of SV2C expression suggests that it may be used as a specific synaptic marker in the study of degenerative diseases, such as Parkinson’s disease. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SV2C and, to a lesser extent, SV2A and SV2B of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of SV2C of rat origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of SV2C of rat origin |
| Entrez Gene | 22987 |
|---|
| Application Notes | recommended for detection of SV2C and, to a lesser extent, SV2A and SV2B of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
