| Product Name | HOP-1 Antibody (Ce-149) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Human presenilin proteins have been implicated in the development of Alzheimer’s disease (1-3). Several presenilin homologs have been identified in C. elegans, including SEL-12, HOP-1 and SPE-4 (4-6). Reducing or eliminating SEL-12 activity causes an egg-laying defective (Egl) phenotype in C. elegans (4-5). HOP-1 activity can rescue the egg-laying defect of the SEL-12 mutant (4). SEL-12 and HOP-1 are therefore thought to act as redundant promoters of Notch-pathway signaling by facilitating the activity of LIN-12 and GLP-1 (4-5). SPE-4 is an integral membrane protein localized within specific organelles responsible for spermatogenesis(6). Mutation of SPE-4 prevents cytokinesis during meiosis, preventing spermatogenesis (6). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of HOP-1 of C. elegans origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 4-149 of HOP-1 of C. elegans origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 4-149 of HOP-1 of C. elegans origin |
| Application Notes | recommended for detection of HOP-1 of C. elegans origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
