ABCG1 (also designated ABC8 or human white gene), a member of the evolutionary conserved family of ATP-binding cassette (ABC) transporters, exhibits high homology with the Drosophila white gene (1–3). ABC transporters couple the energy of ATP hydrolysis to the translocation of various molecules across biological membranes (4–6). These proteins contain characteristic ATP-binding domains and transmembrane domains which form a channel-like structure for transport (4). ABCG1 functions to regulate cholesterol and phospholipid transport in macrophages (7). ABCG1 is highly expressed in several tissues, including brain, spleen, lung and placenta, and has been localized to the cell surface and intracellular compartments of cholesterol-laden macrophages (3,7).
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of ABCG1 of mouse, rat and human origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 336-400 of ABCG1 of human origin
Tissue Specificity
epitope corresponding to amino acids 336-400 of ABCG1 of human origin