| Product Name | cathepsin H Antibody (H-130) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 151-280 mapping to the heavy chain of cathepsin H of human origin |
| Modification Notes | Cathepsin H (also designated N-benzoylarginine-beta-naphthylamide hydrolase, aleurain, cathepsin B3 or cathepsin BA) is a lysosomal cysteine proteinase that mediates degradation of lysosomal proteins. Cathepsin H is a disulfide-linked heavy and light chain dimer produced from a single precursor protein. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Elevated levels of cathepsin H correlates with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. Full-length and truncated cathepsin H [12-amino acid deletion in the signal peptide region (CTSHDelta10-21)] are expressed in prostate tissues, LNCaP, PC-3 and DU-145 prostate cancer cell lines. Cathepsin H mediates maturation of the biologically active surfactant protein-B (SP-B) peptide. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of cathepsin H of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 151-280 mapping to the heavy chain of cathepsin H of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 151-280 mapping to the heavy chain of cathepsin H of human origin |
| Entrez Gene | 1512 |
|---|
| Application Notes | recommended for detection of cathepsin H of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
