Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of Islets of Langerhans.Application
Western blot analysis of human recombinant Amylin fusion protein.| Product Name | Amylin Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 40-89 mapping at the C-terminus of the Amylin precursor of human origin |
| Modification Notes | Adrenomedullin (AM), alpha- and beta-calcitonin gene-related peptide (CGRP), calcitonin (CT) and Amylin are homologous polypeptides with overlapping biological actions, such as vasodilatation and inhibition of bone resorption. Amylin (Islet/insulinoma amyloid polypeptide or IAPP) is a 37 amino acid monomeric polypeptide isolated from pancreatic amyloid. This protein is a major component of amyloid-rich pancreatic extracts of type 2 diabetic patients. Amylin has cysteine residues in positions 2 and 7, a feature found in all known calcitonin gene-related peptides, and shows 46% amino acid sequence homology with CGRP II. Demonstrated immunochemically in normal beta cells of several mammals, Amylin likely plays an important role in pancreatic islet function. The gene that encodes Amylin maps to human chromosome 12p12.3-p12.1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of Amylin precursor and active peptide of human and, to a lesser extent, mouse and rat origin by WB, IP, IF, IHC(P) and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 40-89 mapping at the C-terminus of the Amylin precursor of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 40-89 mapping at the C-terminus of the Amylin precursor of human origin |
| Entrez Gene | 3375 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of Islets of Langerhans.
Application
Western blot analysis of human recombinant Amylin fusion protein.| Application Notes | recommended for detection of Amylin precursor and active peptide of human and, to a lesser extent, mouse and rat origin by WB, IP, IF, IHC(P) and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
