| Product Name | urotensin II Antibody (FL-124) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-124 of urotensin II of human origin |
| Modification Notes | Two major regulatory peptides were originally isolated from fish urophysial extracts, Urotensin I and II (1). In both frog and human, the Urotensin II sequence is located at the carboxy-terminal position of the precursor (2). Human Urotensin II is composed of only 11 amino acid residues, while fish and frog Urotensin II possess 12 and 13 amino acid residues, respectively (2). The cyclic region of Urotensin II, which is responsible for the biological activity of the peptide, has been fully conserved from fish to human (2). However, several substitutions have occurred in the amino-terminal region of the molecule (1). A human G protein-coupled receptor, GPR14, is the Urotensin II receptor (3). Human Urotensin II is found within both vascular and cardiac tissue, including coronary atheroma, and effectively constricts isolated arteries from nonhuman primates (3). Urotensin II may act as an autocrine and/or paracrine hormone rather than as a circulating hormone, by playing an important role in the development of ventricular hypertrophy induced by chronic hypoxia (4). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of urotensin II precursor and active peptide of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-124 of urotensin II of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-124 of urotensin II of human origin |
| Entrez Gene | 10911 |
|---|
| Application Notes | recommended for detection of urotensin II precursor and active peptide of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
