Application
Western blot analysis of JAK3 expression in HuT 78 whole cell lysate.Application
Antibodies tested include JAK3 (B-12): (A) and JAK3 (C-21): (B).Application
Western blot analysis of JAK3 expression in HuT 78 (A) and MOLT-4 (B) whole cell lysates.| Product Name | JAK3 Antibody (C-21) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of JAK3 of human origin |
| Modification Notes | JAK3 (Janus kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAChIP |
| recommended for detection of JAK3 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of JAK3 of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of JAK3 of human origin |
| Entrez Gene | 3718 |
|---|
Application
Western blot analysis of JAK3 expression in HuT 78 whole cell lysate.
Application
Antibodies tested include JAK3 (B-12): (A) and JAK3 (C-21): (B).
Application
Western blot analysis of JAK3 expression in HuT 78 (A) and MOLT-4 (B) whole cell lysates.| Application Notes | recommended for detection of JAK3 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
