Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human epididymus tissue showing nuclear staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Western blot analysis of CDKN3 expression in HeLa whole cell lysate.Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor showing cytoplasmic staining.| Product Name | CDKN3 Antibody (C-18) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of CDKN3 of human origin |
| Modification Notes | Cyclin-dependent kinase inhibitor 3 (CDKN3), also designated Cdk2-associated dual specificity phosphatase, cyclin-dependent kinase interactor 1 (CDI1), CIP2, KAP or KAP1, belongs to the protein-tyrosine phosphatase family. CDKN3, a cyclin-dependent kinase inhibitor, interacts and dephosphorylates Cdk2 kinase, which prevents Cdk2 kinase activation. CDKN3 is important in cell cycle regulation. It is a dual specificity phosphatase that is active toward substrates which contain phosphotyrosine or phosphoserine residues. CDKN3 does not interact with Cdk4, but can interact with other cyclin-dependent kinases such as Cdc2, Cdk2 and Cdk3. The gene encoding for the CDKN3 protein maps to chromosome 14q22. This gene has been noted to be mutated, overexpressed or deleted in many cancers. Defects in the CDKN3 gene may may be implicated in hepatocellular carcinoma (HCC). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of CDKN3 p34 of human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of CDKN3 of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of CDKN3 of human origin |
| Entrez Gene | 1033 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human epididymus tissue showing nuclear staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Western blot analysis of CDKN3 expression in HeLa whole cell lysate.
Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor showing cytoplasmic staining.| Application Notes | recommended for detection of CDKN3 p34 of human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
