| Product Name | ZNF354A/B Antibody (H-60) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 265-324 mapping within an internal region of ZNF354A of human origin |
| Modification Notes | ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krueppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in adult kidney, ZNF354A functions as a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple C2H2-zinc fingers. ZNF354A is localized to the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma. ZNF354B (zinc finger protein 354B) is a 612 amino acid nuclear protein that also belongs to the Krueppel C2H2-type zinc-finger family and is thought to play a role in transcriptional regulation events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ZNF354A/B of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 265-324 mapping within an internal region of ZNF354A of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 265-324 mapping within an internal region of ZNF354A of human origin |
| Application Notes | recommended for detection of ZNF354A/B of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
