Application
Western blot analysis of OCT2 expression in Hep G2 (A), Raji (B) and Jurkat (C) whole cell lysates and human liver (D), human kidney (E) and rat kidney (F) tissue extracts.| Product Name | OCT2 Antibody (H-62) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver, while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT2, also known as SLC22A2, is a multi-specific transporter protein localizing to the basolateral and luminal membranes of the kidney distal tubule and proximal tubules. OCT2 is responsible for mediating the pH-sensitive tubular uptake of organic compounds from circulation. An additional splice variant exists for OCT2, namely OCT2-A. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of OCT2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 290-351 mapping within an internal region of OCT2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 290-351 mapping within an internal region of OCT2 of human origin |
| Entrez Gene | 6582 |
|---|
Application
Western blot analysis of OCT2 expression in Hep G2 (A), Raji (B) and Jurkat (C) whole cell lysates and human liver (D), human kidney (E) and rat kidney (F) tissue extracts.| Application Notes | recommended for detection of OCT2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
