| Product Name | VE-cadherin-2 Antibody (H-177) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy-terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including ∫-catenin, to regulate cadherin function. VE-caderhin-2, also known as PCDH12 (protocadherin 12), VECAD2 or PCDH12, is a 1,184 amino acid single-pass type I membrane protein that is highly expressed in vascularized tissues, including heart and placenta. VE-caderhin-2 may play an important role in cell-cell interactions and may promote homotypic calcium-dependent aggregation and adhesion at intercellular junctions. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of VE-cadherin-2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 457-633 mapping within an internal region of VE-cadherin-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 457-633 mapping within an internal region of VE-cadherin-2 of human origin |
| Entrez Gene | 51294 |
|---|
| Application Notes | recommended for detection of VE-cadherin-2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
