| Modification Notes |
Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF385A (zinc finger matrin-type protein 385A), also known as HZF (hematopoietic zinc finger protein), RZF (retinal zinc finger protein) or ZNF385, is a 366 amino acid protein that contains three matrin-type zinc fingers. The matrin-type zinc finger, which is very similar in structure to the classical DNA-binding C2H2 zinc finger, was first identified in the protein matrin-3. The matrin-type zinc finger has also been identified in several spliceosome RNA-binding proteins, suggesting a role in pre-mRNA binding. ZNF385A is expressed predominantly in the retina, localized to the nucleus as well as the cytoplasm. Two isoforms of ZNF385A exist due to alternative splicing events. |