Application
Western blot analysis of STAMBPL1 expression in non-transfected: (A) and mouse STAMBPL1 transfected: (B) 293T whole cell lysates and HeLa (C) and Jurkat (D) nuclear extracts.| Product Name | STAMBPL1 Antibody (H-110) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | STAMBPL1 (STAM-binding protein-like 1), also known as AMSH-FP, AMSH-LP (associated molecule with the SH3 domain of STAM like protein) or ALMalpha, is a 436 amino acid protein that belongs to the peptidase M67C family, contains one MPN domain and a JAMM motif that is essential for protease activity. Existing as two alternatively spliced isoforms, STAMBPL1 is a ubiquitously expressed protein that binds two zinc ions per subunit and acts as a zinc metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. The gene that encodes STAMBPL1 maps to human chromosome 10q23.31. Chromosome 10 contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of STAMBPL1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 171-280 mapping within an internal region of STAMBPL1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 171-280 mapping within an internal region of STAMBPL1 of human origin |
| Entrez Gene | 57559 |
|---|
Application
Western blot analysis of STAMBPL1 expression in non-transfected: (A) and mouse STAMBPL1 transfected: (B) 293T whole cell lysates and HeLa (C) and Jurkat (D) nuclear extracts.| Application Notes | recommended for detection of STAMBPL1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
