| Modification Notes |
SLC26A11 (solute carrier family 26, member 11) is a 606 amino acid multi-pass membrane protein that belongs to the SLC26A/SulP transporter family. Containing one STAS domain, the SLC26A11 protein exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC). SLC26A11 is detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart. Containing 18 exons, the SLC26A11 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, mosquito, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea and N.crassa, and maps to human chromosome 17q25.3. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. |